Clinical Studies Summary
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Clinical Safety and Efficacy of Dual Wavelength Low-Level Light Therapy in Androgenetic Alopecia: A Double-Blind Randomized Controlled Study
By Thomas
• 2024
• Journal: Dermatol Surg
Abstract: “One hundred sixty subjects were randomized. Ninety-one subjects were excluded for the per-protocol analysis.” “Although the primary endpoint (mean change in non-vellus hair count from baseline to week 16) did not reach statistical significance in the individual study arms, in the pooled analysis (combining the 3 active study arms), there was a statistically significant (p = .033) difference versus sham. The pooled study cap group achieved 28.5 more hairs per cm2 when compared with sham.” Comment 1: It seems a lot of participants dropped out, largery due to noncompliance. Comment 2: Queen and Avram published a commentary to the paper: “(…) Interestingly, in this study, both red and blue light wavelengths appeared to show hair growth according to different measures (…)”
One Sentence Outcome:”One hundred sixty subjects were randomized. Ninety-one subjects were excluded for the per-protocol analysis.” “Although the primary endpoint (mean change in non-vellus hair count from baseline to week 16) did not reach statistical significance in the…
Study Parameters:Notes: Blue light
Device Parameters: Wavelength: 625+ 660 425 425+ 625+ 660
Evidence Level:Randomized controlled trial
Study Type: Human Randomized trial, double-blind 160 participants (only 69 completed ?) ⌛ 26 weeks
Outcome Direction: Positive
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Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis
By Feldman
• 2023
• Journal: Front Med (Lausanne)
Abstract:
One Sentence Outcome:
Study Parameters:
Device Parameters: Wavelength: “Some TH regrowth can be expected from most AGA treatments with less variability in women than men. Responses to drug treatments were rapid, showing strong early efficacy followed by the greatest resistance effects from flatlining to loss of regrowth after 12-16 weeks. Finasteride, Minoxidil 2% and Viviscal in men were not statistically different from Placebo. LLLT appeared more efficacious than pharmaceuticals. The natural product formulation ALRV5XR showed better efficacy in all tested parameters without signs of treatment resistance (see Graphical abstract).”
Evidence Level:Systematic review / Meta-analysis
Study Type: Systematic review & network meta-analysis
Outcome Direction: Unclear / review
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Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review
By de Lima
• 2025
• Journal: Photochem Photobiol
Abstract:
One Sentence Outcome:
Study Parameters:Notes: Blue light
Device Parameters: Wavelength: “This qualitative systematic review, conducted in accordance with PRISMA guidelines, analyzed 37 in vitro and in vivo studies published between 2002 and 2024, retrieved from databases including MEDLINE/PubMed, EMBASE, and LILACS, with a focus on the effects of photobiomodulation (PBM) with blue light (450-470 nm) in pre-clinical cancer models. BL demonstrated anti-tumor potential by reducing cell viability, proliferation, migration, and invasion, as well as increasing ROS production and inducing apoptosis. In animal models, BL also inhibited tumor growth, metastasis, and improved survival. Despite the encouraging findings, considerable methodological heterogeneity and insufficient reporting of dosimetric parameters compromise the reproducibility and comparability of results across studies. These findings underscore the therapeutic potential of BL in oncology and highlight the need for standardized protocols to support clinical translation.”
Evidence Level:Systematic review / Meta-analysis
Study Type: Systematic review
Outcome Direction: Unclear / review
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Bedinvetmab, alone or in combination with photobiomodulation and pulsed electromagnetic field therapy, on pain and quality of life in dogs with hip osteoarthritis
By Cidral
• 2026
• Journal: Vet Res Commun
Abstract: “These findings provide preliminary evidence that the combination of bedinvetmab and physiotherapy enhances pain control and promotes better quality of life in dogs with OA.”
One Sentence Outcome:In dogs with hip osteoarthritis, bedinvetmab combined with PBM/PEMF and physiotherapy was associated with improved pain control and quality of life.
Study Parameters:Dog (n = 30)
Device Parameters: Wavelength: 808.0 nm; Power: 1000.0 mW; PBM+PEMF
Evidence Level:Level 2b (small veterinary clinical study)
Study Type: Veterinary clinical study
Outcome Direction: Positive / supportive
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Home-based transcranial photobiomodulation improves cognitive function in mild cognitive impairment due to Alzheimer’s disease: A randomized, double-blind, placebo-controlled confirmatory trial
By Chun
• 2026
• Journal: J Alzheimers Dis
Abstract: “Active tPBM significantly improved cognitive performance compared with the placebo. Mean MoCA-K scores increased by 3.87 ± 2.51 points in the active group versus a 0.74 ± 2.85 point decline in the placebo group (p < 0.001). K-MMSE2 scores improved significantly (p < 0.001). CERAD-K showed a significant between-group difference at week 13 (p < 0.001), while GDepS scores remained unchanged. No device-related adverse events occurred, and adherence to home-based treatment was high."
One Sentence Outcome:”Active tPBM significantly improved cognitive performance compared with the placebo. Mean MoCA-K scores increased by 3.87 ± 2.51 points in the active group versus a 0.74 ± 2.85 point decline in the placebo group (p < 0.001). K-MMSE2 scores improved...
Study Parameters:Sessions: 72 / 12 weeks; Notes: At-home PBM
Device Parameters: Wavelength: 808
Evidence Level:Randomized controlled trial
Study Type: Human Randomized trial, double-blind 26 participants ⌛ 12 weeks
Outcome Direction: Positive
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Synergistic Enhancement of Cisplatin Anticancer Efficacy by Photobiomodulation Therapy: A Systematic Review
By Jafarzadeh
• 2025
• Journal: Photobiomodul Photomed Laser Surg
Abstract:
One Sentence Outcome:
Study Parameters:
Device Parameters: Wavelength: “Most in vitro studies showed a synergistic effect, with enhanced cancer cell inhibition, apoptosis induction, and reduced cell viability compared with Cis alone. The animal model confirmed these findings, showing PBMT mitigated Cis-induced acute renal failure.”
Evidence Level:Systematic review / Meta-analysis
Study Type: Systematic review (preclinical research)
Outcome Direction: Unclear / review
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Reduced Morphine Consumption with Photobiomodulation in Head and Neck Cancer: A Matched Cohort of 280 Cases
By Giraud
• 2026
• Journal: Photobiomodul Photomed Laser Surg
Abstract: “Morphine use was significantly lower in the PBM group at the end of RT (22.9 vs. 37.4 mg/day; p = 0.002) and 1 month post-RT (10.3 vs. 27.2 mg/day; p = 0.0001). No morphine was required in 60% of PBM patients compared with 47% of controls.” “Grade 3–4 RIOM at the end of RT occurred in 52 control patients (37.1%) and 51 PBM patients (36.4%). Grade 3 mucositis-free survival curves were nearly identical (p = 0.99) (Supplementary Fig. S3). No significant differences were observed across stratification factors, including chemotherapy, surgery, or tumor site.” “In contrast to opioid use, PBM did not reduce the incidence of grade 3–4 RIOM in our study. The frequency of PBM administration may have contributed to this finding (…)”
One Sentence Outcome:”Morphine use was significantly lower in the PBM group at the end of RT (22.9 vs. 37.4 mg/day; p = 0.002) and 1 month post-RT (10.3 vs. 27.2 mg/day; p = 0.0001). No morphine was required in 60% of PBM patients compared with 47% of controls.” “Grade 3–4…
Study Parameters:
Device Parameters: Wavelength: 660+ 810
Evidence Level:Clinical study
Study Type: Human Retrospective study 280 patients
Outcome Direction: Mixed
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Serial Sessions of a Novel Low-Level Light Therapy Device for Home Treatment of Dry Eye Disease
By Giannaccare
• 2023
• Journal: Ophthalmol Ther
Abstract: “One week of serial sessions of a newly developed LLLT device for home use significantly improved tear film production and stability along with ocular discomfort symptoms in patients with DED owing to MGD. These findings open up a new scenario for patients with MGD who can enjoy the unique benefits of LLLT at home.”
One Sentence Outcome:”One week of serial sessions of a newly developed LLLT device for home use significantly improved tear film production and stability along with ocular discomfort symptoms in patients with DED owing to MGD. These findings open up a new scenario for patients…
Study Parameters:Sessions: 4 (every other day); Notes: PBM device design: toothbrush
Device Parameters: Wavelength: 625; Irradiance: 0.035; Fluence: 32
Evidence Level:Clinical study
Study Type: Human Single-arm trial 17 participants ⌛ 2-5 treatment sessions -> 3-5 week follow-up
Outcome Direction: Positive
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Red and Green LED Light Therapy: A Comparative Study in Androgenetic Alopecia
By Tantiyavarong
• 2024
• Journal: Photodermatol Photoimmunol Photomed
Abstract: “Both red and green LED therapies effectively enhanced hair growth, increasing density and thickness over 6 months. Red LED demonstrated superior improvements in specific measures. Consequently, both therapies present safe and viable alternatives for the management of AGA, expanding the repertoire of available treatment options.”
One Sentence Outcome:”Both red and green LED therapies effectively enhanced hair growth, increasing density and thickness over 6 months. Red LED demonstrated superior improvements in specific measures. Consequently, both therapies present safe and viable alternatives for the…
Study Parameters:Time: 1200; Notes: Wavelength comparison
Device Parameters: Wavelength: green red; Fluence: 40
Evidence Level:Preclinical / animal study
Study Type: Human ⚔ Comparison study, self-controlled 17 participants ⌛ 6 months
Outcome Direction: Unclear / review
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The Effects of Photobiomodulation Therapy on Xenopus laevis Embryonic Epithelium
By Lloyd
• 2025
• Journal: Photobiomodul Photomed Laser Surg
Abstract: “This study demonstrates that PBMT can have significant effects on the epithelial tissue of X. laevis. The PBMT-induced abnormal tissue structures represent a loss of tissue polarization and cellular organization along the tail edge, both of which are essential to maintaining tissue homeostasis.”
One Sentence Outcome:”This study demonstrates that PBMT can have significant effects on the epithelial tissue of X. laevis. The PBMT-induced abnormal tissue structures represent a loss of tissue polarization and cellular organization along the tail edge, both of which are…
Study Parameters:
Device Parameters: Wavelength: 660; Fluence: 2.08; Energy: 2.25
Evidence Level:Preclinical / animal study
Study Type: Xenopus laevis tadpoles
Outcome Direction: Positive
