Real Relief, Right at Home

Safe, Soothing Red Light Therapy for Pets in Pain

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”The Luma helped my sweet Labrador with his chronic pain from the comfort of our home! Krieger is an older tripawd with back problems who uses a wheelchair for longer walks. He gets pain flare-ups that need support. I’m thankful the vet and physical therapist recommended The Luma, we will definitely be using it again!” -Abi

When your pet is hurting, you need clarity fast.
See whether your pet is a strong candidate for red light therapy, learn how it works, and get a plan for what to do next.

Krieger

Written by: Alon Landa
Medically reviewed by: Kristy Williams, CVT, CCFT (Specialties: Pet rehabilitation, pain management, photobiomodulation)

Reviewed: [April 2026]
Updated: [April 2026]

This page is part of MedcoVet’s clinical education library on photobiomodulation in veterinary medicine. It is designed to explain where red light therapy may fit into pain management for dogs and cats, where evidence is strongest, where caution is needed, and how home treatment compares with medication, rehabilitation, and in-clinic care.

Not sure where to start?

Want the short version before you dive in?
The Red-Light Therapy Roadmap explains:

  • How red & near-infrared light calm inflammation
  • When it’s safe (and when to wait)
  • How to spot your dog’s “green light” for treatment

Sprite


Can red light therapy help relieve pain in dogs and cats?

Photobiomodulation, also called PBM, red light therapy, low-level laser therapy, LED therapy, cold laser, and near-infrared therapy, refers to the same therapeutic category using light energy to influence cellular biology. In dogs and cats, PBM may help reduce pain and inflammation, support blood flow, and improve function in conditions such as arthritis, soft tissue injury, post-surgical recovery, and some forms of nerve pain. It is best used as part of a broader veterinary pain management plan based on diagnosis, tissue depth, treatment frequency, and clinical goals.


Real pain relief for dogs and cats, from home

Real pain relief for dogs and cats, from home

When a pet is in pain, everything changes. Dogs and cats may slow down, hide, limp, stop jumping, avoid stairs, sleep differently, or react when touched. Pain in dogs and cat pain can come on suddenly after surgery or injury, or build over time with arthritis, osteoarthritis, hip dysplasia, nerve pain, or other disease.

The MedcoVet Luma is built for pain relief for dogs and pain relief for cats using photobiomodulation. In veterinary medicine, PBM is used to support pain management, tissue repair, blood flow, and modulation of inflammation. The MedcoVet Luma uses red and near-infrared light within this therapeutic category as part of an at-home treatment approach for dogs and cats.

If you are looking for pain relief, pain management, and a way to help your pet from home without reaching for human pain meds from the medicine cabinet, this page will walk you through what pain is, how PBM works, when it helps, when it should not be used, and how the MedcoVet Luma fits into a smart treatment plan.


What is pain in dogs and cats?

Pain is not just one thing. A dog’s pain may be mild, moderate pain, or severe pain. It may be short term or long term. It may come from the joints, muscles, nerves, spine, skin, mouth, stomach, or another part of the body. Cat pain can look different from pain in dogs, but both dogs and cats feel pain, and both may hide signs until the problem is more advanced.

Common types of pain in pets

Acute pain

Acute pain starts suddenly. It often happens after surgery, an injury, a dental procedure, a strain, a sprain, or another obvious event. Acute pain can cause swelling, discomfort, guarding, limping, restlessness, or changes in behavior.

Chronic pain

Chronic pain lasts longer and may build slowly. It is common with arthritis, osteoarthritis, hip dysplasia, spine problems, long-term inflammation, or disease. Many dogs and many cats with chronic pain do not cry out. Instead, they move less, sleep more, stop jumping, or seem less social.

Inflammatory pain

Inflammatory pain is linked to swelling and irritation in tissue. Arthritis, injury, surgery, and other conditions can all lead to pain and inflammation.

Neuropathic or nerve pain

Nerve pain involves the nervous system. It can happen with back problems, IVDD, nerve injury, or disease affecting nerve tissue. Nerve pain may feel sharp, strange, or hard to localize.

Signs of pain

Signs of pain are not always dramatic. Watch for:

  • limping
  • stiffness
  • licking one area
  • shaking
  • trouble getting up
  • reluctance to jump
  • posture changes
  • hiding
  • irritability
  • reduced appetite
  • slower walks
  • less interest in play

Other signs can include changes in sleep, grooming, facial expression, breathing, or willingness to be touched. In cats, other signs may include crouching, reduced grooming, hiding, or reluctance to use stairs or the litter box.


Why human pain meds are dangerous for pets

Why human pain meds are dangerous for pets

Many people want to help fast, but human pain meds should not be given unless a veterinarian specifically tells you to do so. Human pain meds like ibuprofen and aspirin can cause serious side effects in dogs and cats, including stomach injury, digestive problems, blood clotting issues, platelet function problems, kidney damage, and liver damage. Worse side effects can be seen in small dogs, cats, seniors, or pets with kidney disease, liver disease, cancer, or other health concerns.

Even pain relievers that seem normal for humans may create major risk for pets. Dose, body size, species, disease status, blood work, and other drugs all matter. Some pain medications used in veterinary medicine are FDA approved for certain uses, while some other medications are used based on veterinary science and clinical judgment. Either way, medication choice should come from your veterinarian, not the medicine cabinet.

That is one reason more pet owners look for ways to manage pain that do not depend only on drugs, especially for long term pain management.

Looking for safer at-home options?

Our Crash Course walks through what red light therapy can and cannot do, how it compares to other approaches, and where it may fit into a broader pain management plan.

Apollo


What is PBM and how does it work for pain?

Photobiomodulation, also called PBM, red light therapy, or light-based pain treatment, uses specific wavelengths of light to affect how cells function. The MedcoVet Luma uses red and near-infrared light as part of a pain management approach designed for pets.

How PBM works inside the body

1. Mitochondria and ATP

PBM acts on the mitochondria, which help cells make energy. When cells make more ATP, they have more energy for repair, recovery, and normal function. This matters in tissue under stress from inflammation, surgery, arthritis, or injury.

2. Cytokines and inflammation

Pain and inflammation often rise together. PBM can help influence inflammatory signaling, including cytokines that contribute to swelling, tissue irritation, and discomfort. That matters for chronic pain, osteoarthritis, post-op recovery, and soft tissue injury.

3. Blood flow

PBM may help improve blood flow to the treatment area. Better blood flow can support oxygen delivery, nutrient delivery, and waste removal, all of which matter when the goal is to relieve pain and help tissue recover.

4. The nervous system and nerve pain

PBM may help calm pain signaling in the nervous system and support tissue around irritated nerves. That is one reason it is often discussed for nerve pain, spine pain, and chronic pain states where the body stays stuck in a pain cycle.

Why this matters

PBM does not work like many pain meds that simply block symptoms for a period of time. It aims to support the tissue and processes underneath the pain. That makes it useful for pain relief, pain management, and helping control pain as part of a broader plan.

For a broader review of mechanism, dosing logic, wavelength selection, safety, and device considerations, see Science of Red Light Therapy.


When red light therapy works best for pain

When red light therapy works best for pain

The MedcoVet Luma is often most useful when pain is linked to inflammation, tissue stress, or poor function in muscles, joints, or nerves.

Common use cases

Arthritis and osteoarthritis

Arthritis is one of the most common reasons people look for pain relief for dogs and pain relief for cats. PBM may help manage pain, reduce stiffness, and support more comfortable movement in pets with osteoarthritis and other chronic joint disease.

Hip dysplasia and joint stress

Dogs with hip dysplasia, older dogs, active dogs, and some small dogs may all need long term pain management. PBM can fit well into a plan that may also include rehab, weight control, joint supplements, fish oil, exercise changes, and prescribed pain medications.

Injury

PBM is often used to relieve pain linked to sprains, strains, soreness, overuse, or trauma. It can be part of early support and also part of a longer recovery plan.

Surgery and post-op recovery

After surgery, swelling, discomfort, and tissue irritation are common. PBM is often used to help manage pain and support healing during recovery.

Nerve pain and back pain

Some pets with nerve pain, back pain, or spine-related issues may benefit from a treatment plan that includes PBM.

Want to know whether your pet’s condition is a strong fit?

Start with the Quiz for a quick candidacy check, or book a Free Consult if your pet has a more complex history, multiple conditions, or severe pain.

📋 Take the Quiz | 🩺 Book a Consult

Ghillie


When NOT to use red light therapy

Red light therapy is not for every situation. It should not be used casually over every problem without thought.

Avoid or pause use when:

  • your pet has a tumor, suspected cancer, or an unknown lump that has not been assessed
  • there is an active infection that needs veterinary diagnosis and treatment
  • you would need to shine the device directly into the eyes
  • the diagnosis is unclear and severe pain is present
  • your pet is declining quickly, non-weight-bearing, unable to urinate, or showing emergency symptoms

If a pet has more severe pain, rapid swelling, sudden collapse, severe nerve signs, or other signs that feel urgent, see a veterinarian first. PBM can be a useful treatment tool, but it does not replace diagnosis when a serious disease, cancer, fracture, infection, or neurologic emergency is possible.

Need help sorting out red flags?

The Quiz is a good first filter. If your pet has a more complex case, recent surgery, neurologic signs, or a diagnosis that raises questions, a Free Consult is the better next step.

📋 Take the Quiz | 🩺 Book a Consult

Anderson


Safety section

Is red light therapy safe?

When used correctly, PBM is generally considered a low-risk, non-invasive treatment option in veterinary medicine. That is a major reason many pet owners look at it for pain relief and long term pain management.

Eye safety

Do not shine treatment light directly into the eyes.

Pregnancy context

If a pet is pregnant, ask your veterinarian before use. Use in pregnancy should be handled thoughtfully because treatment goals and target areas matter.

Infection context

If the area may be infected, the first step is veterinary guidance. Infection needs proper diagnosis and treatment.

Medication context

PBM can often be used alongside pain medications, NSAIDs, gabapentin, joint supplements, fish oil, rehab, and other medications, but your veterinarian should help you decide what combination makes sense for your pet’s pain, overall health, blood work, liver status, kidney disease risk, and other drugs already in use.


Red light therapy vs pain medications

Pain medications matter. NSAIDs, gabapentin, and other pain meds are important tools in veterinary medicine. A nonsteroidal anti inflammatory drug may be used to control pain and inflammation. Other medications may be prescribed for nerve pain, surgical discomfort, or disease-specific pain.

Pain medications matter. NSAIDs, gabapentin, and other pain meds are important tools in veterinary medicine. A nonsteroidal anti inflammatory drug may be used to control pain and inflammation. Other medications may be prescribed for nerve pain, surgical discomfort, or disease-specific pain.

But medication is not the whole story.

Where medication helps

  • fast symptom control
  • moderate pain or severe pain support
  • post-op treatment
  • short-term flare management

Where pain medications may have limits

Depending on the drug, pet, dose, and long term use, there can be potential side effects such as:

  • stomach upset
  • digestive problems
  • changes in platelet function
  • blood clotting concerns
  • kidney damage
  • liver damage
  • worse side effects in fragile pets or certain species

PBM is often used because it gives another way to relieve pain and manage pain without adding the same drug burden to the body. For some pets, the best plan is not PBM instead of medication. It is PBM plus medication, plus rehab, plus weight management, plus other treatment steps based on the condition.

Comparing options?

Our Crash Course walks through what red light therapy can and cannot do, how it compares to other approaches, and where it may fit into a broader pain management plan.

Hazel


Can PBM be used with NSAIDs, gabapentin, and other medications?

Yes, often it can. Many veterinarians use PBM as part of a broader pain management plan that may include NSAIDs, gabapentin, joint supplements, fish oil, rehab, surgery recovery care, and other medications. The right treatment mix depends on the source of the pain, whether the pet has kidney disease or liver disease, what other drugs are already being used, and what your veterinarian wants to monitor over time.

PBM can be especially helpful when a pet needs long term support and the goal is to manage pain while being thoughtful about medication load and potential side effects.

Hazel

Want case-specific guidance?

Book a Free Consult to talk through how PBM may fit alongside medication, rehab, supplements, and your veterinarian’s current plan.


At-home vs clinic treatment

Clinic treatment

Clinic laser treatment can be helpful, especially early on or for complex cases. But it often depends on travel, scheduling, cost, and how well the pet tolerates repeated visits. Some dogs and cats do great at the clinic. Others do not.

At-home treatment

At-home PBM makes frequent treatment possible. That matters because consistency is often one of the biggest drivers of success in pain management. Instead of spacing care far apart, you can treat regularly in the real world, where the pet is calm and comfortable.

Why MedcoVet Luma fits this need

The MedcoVet Luma is designed for home use while still being grounded in veterinary science. For many pets, that means more sessions, less stress, and a better shot at steady pain relief.

For broader condition pages, see Red Light Therapy for Dogs and Red Light Therapy for Cats.

Want the step-by-step version?

The Crash Course walks through how red light therapy works in real life, what to expect, and how to think about home treatment versus clinic treatment.

Mizzy


LED vs laser

People often ask whether LED or laser is better for pain relief. The better question is whether the device delivers the right wavelengths, enough useful energy, and a practical treatment format for the target tissue and the actual pet in front of you.

Laser

Laser devices are often used in clinic settings and may be powerful tools in trained hands.

LED

LED-based PBM can also be effective, especially when device design, wavelength choice, treatment consistency, and ease of use support real-world care.

What matters most

  • wavelength
  • dosing
  • treatment frequency
  • contact with the correct area
  • fur management
  • consistency over time

For many dogs and cats, the best device is the one that can actually be used correctly and often enough to manage pain.

Confused by lasers, LEDs, and at-home devices?

Download The Smart Pet Parent’s Guide to Choosing a Red Light Therapy Device for a practical breakdown of what actually matters, including wavelength, irradiance, average power, fur, treatment time, and misleading claims to avoid.

Caspian


Fur and penetration limitations

Fur matters. Thick coats, dark coats, dense undercoats, and body location all affect how much light reaches tissue. That is true whether the goal is to relieve pain from arthritis, soreness, back pain, or another issue.

Factors that affect penetration

  • coat thickness
  • coat color
  • target depth
  • body size
  • treatment angle
  • contact with the skin or parted fur

This is one reason a good pain relief plan should match the actual pet, not just the condition on paper. A small dog with a short coat is different from a large dog with thick fur. A cat with spine pain is different from a dog with hip dysplasia. Good pain management looks at the whole body and the actual use case.


What improves, and when? Week 1 to Week 4

Pain relief is not always instant, but many pets show improvement with consistent use.

Week 1

You may notice:

  • less guarding
  • smoother movement
  • better willingness to walk
  • less licking
  • less tension when touched

Week 2 to Week 3

You may notice:

  • better mobility
  • easier standing up
  • more interest in normal activity
  • better comfort after rest

Week 4 and beyond

You may notice:

  • more stable pain relief
  • fewer flare-ups
  • better day-to-day comfort
  • stronger long term pain management
  • easier integration with rehab, medication, and other support

If a pet has severe pain, advanced disease, or a complex diagnosis, improvement may take longer and may depend on a combination plan.


Conditions where MedcoVet Luma may fit into pain management

The MedcoVet Luma may be part of a treatment plan for:

  • arthritis
  • osteoarthritis
  • hip dysplasia
  • post-surgery discomfort
  • soft tissue injury
  • back pain
  • neck pain
  • chronic pain
  • nerve pain
  • mobility issues
  • age-related pain and stiffness

It is not a replacement for diagnosis, but it can be a valuable tool to relieve pain, support recovery, and help manage pain over time.


Why MedcoVet Luma

The MedcoVet Luma is built around a simple goal: help dogs and cats feel better with practical, science-based pain relief from home.

What makes it different

  • designed around PBM for pets
  • supports pain relief for dogs and pain relief for cats
  • usable at home, where consistency is easier
  • can fit into a treatment plan with pain medications, rehab, and veterinary care
  • gives pet owners a way to manage pain without reaching for human medicine
  • grounded in veterinary medicine and veterinary science

Ready to take the next step?

Choose your shortcut:

  • Take the Quiz if you want a fast candidacy check
  • Get the Roadmap if you want the basics first
  • Download the Ebook if you are comparing devices
  • Watch the Crash Course if you want the full walkthrough
  • Book a Free Consult if you want direct guidance

Take the Quiz | Get The Roadmap | 📋 Get the Guide | 🎬 Watch the Class | 🩺 Book a Consult

Huxley


Clinical summary

Mechanism

Photobiomodulation uses red and near-infrared light to influence cellular function. Proposed mechanisms relevant to pain include mitochondrial stimulation and increased ATP production, modulation of inflammatory cytokines, support for local blood flow, and effects on pain signaling within the nervous system.

Evidence level

Evidence is moderate to strong for pain and functional support in selected inflammatory and musculoskeletal conditions, particularly osteoarthritis, soft tissue injury, and post-surgical recovery. Evidence strength varies by indication, study design, wavelength, irradiance, tissue depth, treatment frequency, and device characteristics.

When it works best

PBM is most commonly used for arthritis, osteoarthritis, hip dysplasia, soft tissue injury, post-operative discomfort, mobility decline, and some forms of back pain or nerve pain. It is most useful when the diagnosis is reasonably clear and treatment is applied consistently over time.

When not to use

PBM should not be used casually over unknown masses, suspected tumors, or areas of possible cancer without veterinary guidance. Caution is also warranted when infection is suspected, when direct eye exposure would occur, or when the pet has severe or rapidly worsening symptoms that require diagnosis before supportive treatment begins.

Limitations

PBM is not a substitute for diagnosis, emergency care, surgery when indicated, or medication when needed. Clinical response varies based on the underlying condition, severity, tissue depth, fur interference, dosing logic, and adherence to treatment frequency.


Clinical questions pet owners ask about red light therapy for pain

Signs of pain in dogs may include limping, stiffness, licking, shaking, slower movement, difficulty rising, reluctance to jump, irritability, hiding, or changes in sleep and appetite. Some dogs with chronic pain do not vocalize. A behavior change may be the clearest sign. Common signs also include whimpering, crying, groaning, or howling, as well as licking or biting at a wound or surgery site. Dogs may show pain by shifting their weight or limping to protect certain areas of their body.

Cat pain is often subtle. Common signs include hiding, crouching, reduced jumping, stiffness, reduced grooming, changes in litter box habits, and decreased social behavior. Cats often mask discomfort until pain is more advanced.

PBM may help improve comfort and function in dogs with arthritis and osteoarthritis, especially when used consistently over time. It is most often used as part of a broader pain management plan that may also include weight management, rehabilitation, medication, and joint support.

Treatment frequency depends on the diagnosis, tissue depth, severity, body area, and whether the goal is short-term relief or long-term pain management. In general, repeated and consistent treatment matters more than occasional use.

Often, yes. PBM is commonly used alongside NSAIDs, gabapentin, rehabilitation, fish oil, joint supplements, and other medications. The correct combination depends on the individual pet, the source of pain, and the veterinarian’s treatment plan.

Lack of improvement should prompt a review of the diagnosis, treatment frequency, dosing logic, fur interference, tissue depth, and overall plan of care. Persistent or worsening pain may indicate that the source of pain is more serious or that another treatment approach is needed.

These therapies do different jobs. Pain medications may help provide faster symptom control, especially in moderate pain or severe pain. PBM is often used to support pain relief and tissue recovery over time. Many pets do best with both, not one or the other.

Do not give ibuprofen, aspirin, acetaminophen, or other human pain meds unless your veterinarian specifically instructs you to do so. Many human pain medications, such as ibuprofen and acetaminophen, are toxic to dogs and should never be given without veterinary guidance. These medications can cause severe side effects in dogs and cats, including stomach injury, blood clotting problems, kidney damage, liver damage, and even death. Acetaminophen can cause red blood cell damage in cats and liver damage in dogs, making it dangerous for pets.

Veterinarians often prescribe NSAIDs for dogs to control pain and inflammation associated with osteoarthritis and after soft tissue and orthopedic surgery. Common FDA-approved NSAIDs for dogs include carprofen, deracoxib, firocoxib, and grapiprant, which help relieve pain by decreasing inflammation. Specialized pain medications like gabapentin and Librela may also be prescribed. Gabapentin is used to manage nerve pain, although its safety and effectiveness are not well established in dogs. Only a few opioids are FDA-approved for use in animals, including dogs, and they are typically reserved for more severe pain.

Yes. Veterinarians may require blood tests before prescribing pain medications to ensure the dog’s liver and kidney functions are adequate for safe medication use. Long-term use of NSAIDs in dogs may require regular blood tests to monitor liver and kidney function due to potential side effects.

Common side effects of NSAIDs in dogs include ulcers in the stomach and intestines, kidney failure, liver failure, and even death in some cases. NSAIDs can cause side effects in the digestive tract, kidneys, and liver due to their interference with prostaglandins, which protect these organs. Opioids can cause side effects such as slow or shallow breathing, decreased heart rate, excessive salivation, nausea, vomiting, and lethargy.

Yes. CBD oil can reduce pain, inflammation, and anxiety in dogs, with minimal side effects such as sedation or diarrhea. Physical therapies such as acupuncture and laser therapy are effective in reducing inflammation and managing chronic pain without medication. Natural alternatives include omega-3 fatty acids, glucosamine, chondroitin, turmeric, and avocado and soybean unsaponifiables (ASUs). Fish oil supplements containing omega-3 fatty acids can help slow joint degeneration and may allow for reduced NSAID use. Turmeric and curcumin supplements may have mild anti-inflammatory effects. Complementary therapies also include chiropractic care, physical therapeutic exercises, underwater treadmill rehabilitation, massage, and acupuncture.

Weight management is one of the most effective ways to reduce chronic joint pain in dogs and is often a key part of a comprehensive pain management plan.


Pain relief should not depend on guesswork

If your dog or cat is showing signs of pain, the next step is not to reach for human pain meds. It is to understand what is causing the pain, what treatment options make sense, and how to build a pain management plan that supports your pet’s overall health.

The MedcoVet Luma gives many dogs and cats a practical way to relieve pain from home and manage pain with a treatment approach grounded in veterinary medicine.

No pressure • No obligation • Real clinicians

Gemma

Evidence Citations

  • Bedinvetmab, alone or in combination with photobiomodulation and pulsed electromagnetic field therapy, on pain and quality of life in dogs with hip osteoarthritis

    By Cidral

    • 2026

    • Journal: Vet Res Commun

    Abstract: “These findings provide preliminary evidence that the combination of bedinvetmab and physiotherapy enhances pain control and promotes better quality of life in dogs with OA.”

    One Sentence Outcome:In dogs with hip osteoarthritis, bedinvetmab combined with PBM/PEMF and physiotherapy was associated with improved pain control and quality of life.

    Study Parameters:Dog (n = 30)

    Device Parameters: Wavelength: 808.0 nm; Power: 1000.0 mW; PBM+PEMF

    Evidence Level:Level 2b (small veterinary clinical study)

    Study Type: Veterinary clinical study

    Outcome Direction: Positive / supportive

  • Reduced Morphine Consumption with Photobiomodulation in Head and Neck Cancer: A Matched Cohort of 280 Cases

    By Giraud

    • 2026

    • Journal: Photobiomodul Photomed Laser Surg

    Abstract: “Morphine use was significantly lower in the PBM group at the end of RT (22.9 vs. 37.4 mg/day; p = 0.002) and 1 month post-RT (10.3 vs. 27.2 mg/day; p = 0.0001). No morphine was required in 60% of PBM patients compared with 47% of controls.” “Grade 3–4 RIOM at the end of RT occurred in 52 control patients (37.1%) and 51 PBM patients (36.4%). Grade 3 mucositis-free survival curves were nearly identical (p = 0.99) (Supplementary Fig. S3). No significant differences were observed across stratification factors, including chemotherapy, surgery, or tumor site.” “In contrast to opioid use, PBM did not reduce the incidence of grade 3–4 RIOM in our study. The frequency of PBM administration may have contributed to this finding (…)”

    One Sentence Outcome:”Morphine use was significantly lower in the PBM group at the end of RT (22.9 vs. 37.4 mg/day; p = 0.002) and 1 month post-RT (10.3 vs. 27.2 mg/day; p = 0.0001). No morphine was required in 60% of PBM patients compared with 47% of controls.” “Grade 3–4…

    Study Parameters:

    Device Parameters: Wavelength: 660+ 810

    Evidence Level:Clinical study

    Study Type: Human Retrospective study 280 patients

    Outcome Direction: Mixed

  • Home-use Photobiomodulation for Pain Management and Recovery after Lower Third Molar Extraction: A Pilot Split-Mouth Study

    By Altayeb

    • 2025

    • Journal: J Lasers Med Sci

    Abstract: “The PBM group showed significantly reduced pain (Day 3: P=0.001), swelling (Day 7: P=0.001), and trismus (Day 4: P=0.037), with sustained improvements through Day 7. Analgesic use was significantly lower in the PBM group (Day 4: P=0.001), demonstrating PBM’s analgesic and anti-inflammatory effects.”

    One Sentence Outcome:”The PBM group showed significantly reduced pain (Day 3: P=0.001), swelling (Day 7: P=0.001), and trismus (Day 4: P=0.037), with sustained improvements through Day 7. Analgesic use was significantly lower in the PBM group (Day 4: P=0.001), demonstrating…

    Study Parameters:Sessions: daily for 7 days; Notes: At-home device

    Device Parameters: Wavelength: 630+ 660+ 850+ 940

    Evidence Level:Randomized controlled trial

    Study Type: Human Non-randomized study, split-mouth 12 participants ⌛ 7 days

    Outcome Direction: Positive

  • Dual near-infrared wavelength photobiomodulation accelerates transdermal burn wound repair via anti-inflammatory, pain relief and redox-regulating mechanisms

    By Priyadarshi

    • 2025

    • Journal: J Photochem Photobiol B

    Abstract: “Combined PBMT exhibited a positive synergistic effect on the burn repair process by significantly (P < 0.05) reducing inflammation (NF-κB, TNF-α, IL-1β, NOS-2, IL-6), pain (substance P-receptor, COX-2), and oxidative stress (ROS, 4-HNE adduct, LPO, 3-NT), while increasing redox potential/endogenous antioxidant (Nrf2, catalase), and maintaining cytoprotection (GRP78) seven days post-wounding. These molecular findings were well-supported by histopathological analysis, which indicated decreased mast cell infiltration, exhibiting the potent anti-inflammatory effects of the combined PBMT. Altogether, the current findings demonstrate that dual PBMT synergistically accelerates the repair of full-thickness burns, exhibits analgesic, anti-inflammatory responses, reduces oxidative stress, activates the antioxidant defense pathway, and maintains cellular redox homeostasis. This non-invasive dual NIR PBMT presents a promising translational therapeutic approach for burn repair in clinical care."

    One Sentence Outcome:”Combined PBMT exhibited a positive synergistic effect on the burn repair process by significantly (P < 0.05) reducing inflammation (NF-κB, TNF-α, IL-1β, NOS-2, IL-6), pain (substance P-receptor, COX-2), and oxidative stress (ROS, 4-HNE adduct, LPO, 3-NT),...

    Study Parameters:Notes: Wavelength combination Wavelength comparison

    Device Parameters: Wavelength: 810+ 904 810 904

    Evidence Level:Preclinical / animal study

    Study Type: Rat

    Outcome Direction: Positive

  • Effect Of Photobiomodulation (Low-Level Laser Therapy) In Patients With Knee Osteoarthritis: A Randomized Controlled Trial

    By Maciel

    • 2025

    • Journal: Lasers Med Sci

    Abstract: “Significant reductions in pain (p < 0.05) were observed in the PBM group after treatment, compared to both the placebo and control groups. WOMAC scores showed significant improvements in pain, stiffness, and functional limitations within the PBM group (pre- vs. post-treatment) (p < 0.05), while no significant changes were found in the sham or control groups (p > 0.05).”

    One Sentence Outcome:”Significant reductions in pain (p < 0.05) were observed in the PBM group after treatment, compared to both the placebo and control groups. WOMAC scores showed significant improvements in pain, stiffness, and functional limitations within the PBM group...

    Study Parameters:Area: 0.13 cm2 spot size; Time: -; Sessions: 30 / 10 weeks

    Device Parameters: Wavelength: 790; Power: 120; Irradiance: 0.92; Fluence: -; Energy: 4 /point (9 points of knee)

    Evidence Level:Randomized controlled trial

    Study Type: Human Randomized trial, sham-controlled 73 participants (65 completed) ⌛

    Outcome Direction: Mixed

  • The effects of various physical modalities on pain in patients with knee osteoarthritis: A network meta-analysis

    By Zhou

    • 2025

    • Journal: J Orthop

    Abstract:

    One Sentence Outcome:

    Study Parameters:

    Device Parameters: Wavelength: “The analysis included 64 studies with 3855 patients and 12 physical therapy modalities. Based on the surface under the cumulative ranking curve (SUCRA), the most effective treatments were HILT, ESWT, Hydrotherapy, Land-EX, LLLT, Braces, tDCS, US, IFCs, SWD, Insoles, and TENS.” “HILT appears to be the most effective treatment for pain relief in KOA patients. Further large-scale RCTs are needed to confirm these findings.”

    Evidence Level:Systematic review / Meta-analysis

    Study Type: Meta-analysis (network)

    Outcome Direction: Unclear / review

  • Efficacy of High-Intensity and Low-Level Laser Therapy Combined With Exercise Therapy on Pain and Function in Knee Osteoarthritis: A Systematic Review and Network Meta-analysis

    By Khalilizad

    • 2024

    • Journal: J Lasers Med Sci

    Abstract:

    One Sentence Outcome:

    Study Parameters:

    Device Parameters: Wavelength: “In total, 11 eligible RCTs were included.” “Our analysis revealed significant improvements in the VAS pain and WOMAC function scores on weeks 4 and 8 after interventions in groups treated with LLLT+ET and HILT+ET compared with placebo+ET. Moreover, HILT+ET showed a greater reduction in the VAS pain score (SMD=-1.41; 95% CI: -2.05 to -0.76) and improvement in the WOMAC function score (SMD=-2.20; 95% CI: -3.21 to -1.19) than LLLT+ET in week 8.” “Based on our findings, both HILT+ET and LLLT+ET treatments effectively reduced pain and improved function, but HILT+ET showed a more significant improvement in both outcomes compared to LLLT+ET.”

    Evidence Level:Systematic review / Meta-analysis

    Study Type: Meta-analysis (network)

    Outcome Direction: Unclear / review

  • Ambient green light reduces knee pain in osteoarthritis patients

    By O’Brien

    • 2026

    • Journal: Can J Pain

    Abstract: “With green light therapy (GLT), average WOMAC scores decreased from 44.1 ± 17.5 at baseline to 32.5 ± 16.2 whereas white light therapy (WLT) had no significant effect on arthritis disability scores (39.6 ± 15.3). While both WLT and GLT reduced pain intensity, the analgesic effect of green light was significantly greater.”

    One Sentence Outcome:”With green light therapy (GLT), average WOMAC scores decreased from 44.1 ± 17.5 at baseline to 32.5 ± 16.2 whereas white light therapy (WLT) had no significant effect on arthritis disability scores (39.6 ± 15.3). While both WLT and GLT reduced pain…

    Study Parameters:

    Device Parameters:

    Evidence Level:Evidence review / experimental study

    Study Type: Human

    Outcome Direction: Mixed

  • Low-level laser acupuncture reduces postoperative pain and morphine consumption in older patients with total knee arthroplasty: A randomized placebo-controlled trial

    By Huang

    • 2022

    • Journal: J Integr Med

    Abstract: “Low-level LA gradually reduced older patients’ postoperative pain intensity and morphine consumption within the first 72 h after their TKA for osteoarthritis. Low-level LA may have benefits as an adjuvant pain management technique for clinical care.” Comment: The parameters were insufficiently reported. According to a Google search, it seems the TI-816-3E2 device has a beam area of less than 1 cm2.

    One Sentence Outcome:”Low-level LA gradually reduced older patients’ postoperative pain intensity and morphine consumption within the first 72 h after their TKA for osteoarthritis. Low-level LA may have benefits as an adjuvant pain management technique for clinical care.” …

    Study Parameters:Time: 60 (6p); Notes: Laser acupuncture

    Device Parameters: Wavelength: 808; Power: 300; Energy: 18 (6p)

    Evidence Level:Randomized controlled trial

    Study Type: Human Randomized trial, sham-controlled 82 participants

    Outcome Direction: Positive

  • Effects of early photobiomodulation therapy on motor recovery in patients with incomplete acute cervical spinal cord injury: A multicenter randomized controlled trial

    By Liang

    • 2026

    • Journal: J Orthop Translat

    Abstract: “PBM patients had significantly higher ASIA motor scores at 0.5 months (mean difference, 8.13; 95 % CI, 5.62 to 10.22; P < 0.001) and 3 months (13.33; 95 % CI, 11.01-15.26; P < 0.001), with no significant between-group difference at 6 or 12 months. The PBM group showed higher-but not statistically significant-independent ambulation rates at 3 and 6 months; rates were similar at 12 months. At day 7, CSF levels of GFAP, Tau, S100β, NSE, and NFH were lower with PBM; exploratory proteomics suggested enrichment of synaptic plasticity and repair-related pathways. Scores on SCIM, SF-36, and EQ-5D favored PBM at 3 and 6 months (all P < 0.001), converging by 12 months. Fewer complications occurred with PBM, and no device-related serious adverse events were observed." "Early PBM adjunctive to decompression may improve short-term neurological and functional recovery and reduce CSF markers of neural injury in acute incomplete cervical SCI."

    One Sentence Outcome:”PBM patients had significantly higher ASIA motor scores at 0.5 months (mean difference, 8.13; 95 % CI, 5.62 to 10.22; P < 0.001) and 3 months (13.33; 95 % CI, 11.01-15.26; P < 0.001), with no significant between-group difference at 6 or 12 months. The...

    Study Parameters:Time: 1800; Sessions: 7 / 7 days

    Device Parameters: Wavelength: 810; Power: 300

    Evidence Level:Randomized controlled trial

    Study Type: Human Randomized trial Multicenter 66 participants (56 completed) ⌛ 7-day treatment -> 12-month follow-up

    Outcome Direction: Mixed

About the Author
Alon Landa is the CEO and co-founder of MedcoVet, a leader in at-home red light therapy for pets. With over 20 years of experience in medical technology and firsthand involvement in developing the Luma, Alon combines deep technical knowledge with a passion for improving pet health. He regularly collaborates with veterinarians and pet parents to advance photobiomodulation (PBM) care at home.
 📍 Based in Boston, MA
📖Read more from Alon here

Kristy Williams Medical Reviewer Headshot

About the Medical Reviewer
Clinical Focus: Surgery, anesthesia, canine fitness, injury prevention, agility
Kristy Williams brings over 30 years of experience to the veterinary field. Her career began in the 1990s, working as a civilian for the Army Veterinary Corps at RAF Feltwell in England, where she first discovered her passion for animal care and supporting their families. Upon returning to the United States, Kristy pursued her education and graduated in 2005 as a certified veterinary technician after passing the national exam. She has since gained extensive experience in both general practice and emergency/referral practices.
Read More about Kristy here.